ABSTRACT
OBJECTIVE: To investigate the work capability and its influencing factors in public health workers. METHODS: By the stratified cluster sampling method,2 688 public health workers were selected. The Work Ability Index( WAI)questionnaire was used to measure the work capability. The conscious work pressure was survey. RESULTS: The score of WAI for public health workers was( 37. 1 ± 5. 1),which was in the middle level. Male public health workers had higher score of WAI than that of female workers( P < 0. 01); the scores of WAI for public health workers with municipal units were higher than those with provincial units( P < 0. 05). The work ability decreased with the increase of work pressure(P < 0. 05). The public health workers who had moderate pressure,high pressure and very high pressure were more likely to have reduced work capability than those who had low pressure( P < 0. 01). Female public health workers were more likely to have lower work capability than that of male workers( P < 0. 01). Public health workers with provincial units were more likely to have lower work capability than that of municipal units( P < 0. 01). Workers with high education background,married and in charge of departments were less likely to have low work capability( P < 0. 05). CONCLUSION:s Education background,work pressure,middle and senior level of management were the major contributors of work capability. The key factors to improve work capability of public health workers are to improve educational level,reduce work pressure and create a good promotion platform for public health workers.
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease and it represents the hepatic manifestation of metabolic syndrome, which includes type 2 diabetes mellitus (T2DM), dyslipidemia, central obesity and hypertension. Glucagon-like peptide-1 (GLP-1) analogues and dipeptidyl peptidase-4 (DPP-4) inhibitors were widely used to treat T2DM. These agents improve glycemic control, promote weight loss and improve lipid metabolism. Recent studies have demonstrated that the GLP-1 receptor (GLP-1R) is present and functional in human and rat hepatocytes. In this review, we present data from animal researches and human clinical studies that showed GLP-1 analogues and DPP-4 inhibitors can decrease hepatic triglyceride (TG) content and improve hepatic steatosis, although some effects could be a result of improvements in metabolic parameters. Multiple hepatocyte signal transduction pathways and mRNA from key enzymes in fatty acid metabolism appear to be activated by GLP-1 and its analogues. Thus, the data support the need for more rigorous prospective clinical trials to further investigate the potential of incretin therapies to treat patients with NAFLD.
Subject(s)
Animals , Humans , Clinical Trials as Topic , Dipeptidyl-Peptidase IV Inhibitors , Pharmacology , Therapeutic Uses , Glucagon-Like Peptide 1 , Hypoglycemic Agents , Pharmacology , Therapeutic Uses , Lipid Metabolism , Non-alcoholic Fatty Liver Disease , Drug Therapy , Metabolism , Triglycerides , MetabolismABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease and it represents the hepatic manifestation of metabolic syndrome, which includes type 2 diabetes mellitus (T2DM), dyslipidemia, central obesity and hypertension. Glucagon-like peptide-1 (GLP-1) analogues and dipeptidyl peptidase-4 (DPP-4) inhibitors were widely used to treat T2DM. These agents improve glycemic control, promote weight loss and improve lipid metabolism. Recent studies have demonstrated that the GLP-1 receptor (GLP-1R) is present and functional in human and rat hepatocytes. In this review, we present data from animal researches and human clinical studies that showed GLP-1 analogues and DPP-4 inhibitors can decrease hepatic triglyceride (TG) content and improve hepatic steatosis, although some effects could be a result of improvements in metabolic parameters. Multiple hepatocyte signal transduction pathways and mRNA from key enzymes in fatty acid metabolism appear to be activated by GLP-1 and its analogues. Thus, the data support the need for more rigorous prospective clinical trials to further investigate the potential of incretin therapies to treat patients with NAFLD.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the comprehensive workplace health promotion intervention effect in a pharmaceutical company.</p><p><b>METHODS</b>The evaluation was conducted by using questionnaires, access to information, on-site surveys, satisfaction surveys and interviews.</p><p><b>RESULTS</b>After the intervention, the awareness rate of the staff on "Occupational Disease Prevention Law", occupational disease prevention measures, the definition of hypertension, HIV transmission and high blood pressure, coronary heart disease preventive measures, have been raised from 72.4%, 13.8%, 67.5%, 45.8%, 51.7% to 97.8%, 19.9%, 82.3%, 94.7%, 53.1% respectively. The lifestyle of the staff has been improved, the improvement rate of smoking, drinking, having breakfast 4 times a week and above are 98.5%, 70.2% and 30.6% separately. Out of the 47 evaluation indicators, 41 meet the requirements, 5 basically meet the requirements.</p><p><b>CONCLUSION</b>After implementing workplace health promotion activities, the level of occupational safety and health management of the pharmaceutical company has been enhanced, the physical and mental health of the staff have been promoted. The WHP comprehensive interventions are feasible and effective.</p>
Subject(s)
Humans , Drug Industry , Health Promotion , Occupational Health , Surveys and Questionnaires , WorkplaceABSTRACT
<p><b>OBJECTIVE</b>To compare and analyze the all previous censuses and large-scale surveys on occupational hazard in China, draw lessons from the past, and try to provide references for the development of census or surveys on the occupational hazard in the new period.</p><p><b>METHODS</b>A literature retrieval had been performed mainly on the occupational hazard census and large-scale surveys since the founding of People's Republic of China. Only the survey items carried on a national scale were selected. Some keywords were drawn from these items such as survey time, survey scope, industries, occupational diseases and the rate of examination, organization and technical director, methods and so on. The outcomes and experiences were summarized.</p><p><b>RESULTS</b>Since the founding of People's Republic of China, there were seven occupational hazard census and large-scale surveys carried in China, three of them were about silicosis or pneumoconiosis, two of them were about poison and carcinogens, one was about noise, another one was about the township industrial enterprises.</p><p><b>CONCLUSION</b>Leadership attention was the fundamental guarantee of the success of the survey, sound occupational health management organizations were the base, collaborative relationship with each other was an import factor, and only the interdisciplinary team, scientific design, quality control and incentive mechanism could assure the quality of the survey. The survey should be designed and carried out according to industries.</p>